Recent Publications from Ludwig Center at Harvard Investigators

MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.  Brown, et al, 2015, Cell Reports (Beck and Toker labs)

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.  Patel, et al, 2014, Science (Bernstein lab)

Phthalimide conjugation as a strategy for in vivo target protein degradation. Winter, et al, 2015, Science (Bradner lab)

Loss of negative regulators amplifies RAS signaling. Lock and Cichowski, 2015, Nature Genetics

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.  2015, Montero, et al, 2015, Cell  (Cichowski and Letai labs)

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. De Raedt, et al, 2014, Nature (Cichowski and Bradner labs)

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.  Elia, et al, 2015, Mol Cell (Elledge lab)

Principles of cancer therapy:  oncogene and non-oncogene addiction. Luo, et al, 2009, Nature (Elledge lab)