Louder for longer: Myc amplifies gene expression by extended transcriptional bursting
Publication information:
Lu, D., Jambhekar, A. & Lahav, G. Louder for longer: Myc amplifies gene expression by extended transcriptional bursting. Cell Rep 38, 110470 (2022).
Abstract
Transcription is a complex, dynamic process. Using live single-cell measurements, Patange et al. show, in a recent issue of Cell Reports, that elevated levels of the transcription factor MYC enhance target gene RNA production by increasing the duration but not frequency of transcriptional bursts.