Loss of p53 and genetic evolution in pancreatic cancer: Ordered chaos after the guardian is gone
Publication information:
Wu, B. & Ellisen, L. Loss of p53 and genetic evolution in pancreatic cancer: Ordered chaos after the guardian is gone. Cancer Cell 40, 1276–1278 (2022).
Abstract
A recent Nature study delineates a stepwise genomic evolution during pancreatic cancer development, employing an engineered mutant Kras and heterozygous Trp53 mouse model that identifies cells undergoing Trp53 loss of heterozygosity (LOH). Genetic progression post-Trp53 LOH involves clonal deletions, then genome doubling and subsequent accumulation of subclonal gains and amplifications.