Dissecting the mammary gland one cell at a time
Publication information:
Cristea, S. & Polyak, K. Dissecting the mammary gland one cell at a time. Nat Commun 9, 2473 (2018).
Abstract
Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages.