#   Recent Publications from Ludwig Center at Harvard Investigators 

 



MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy. [Brown, et al, 2015, Cell Reports ](http://www.cell.com/cell-reports/abstract/S2211-1247(15)00502-1?_returnURL=http://linkinghub.elsevier.com/retrieve/pii/S2211124715005021?showall=true)(Beck and Toker labs)

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. [Patel, et al, 2014, Science ](http://www.sciencemag.org/content/early/2014/06/11/science.1254257?explicitversion=true)(Bernstein lab)

Phthalimide conjugation as a strategy for in vivo target protein degradation. [Winter, et al, 2015, Science](http://www.sciencemag.org/content/348/6241/1376.full.pdf?keytype=ref&siteid=sci&ijkey=3suAeKFHayLKk) (Bradner lab)Loss of negative regulators amplifies RAS signaling. [Lock and Cichowski, 2015, Nature Genetics](http://www.ncbi.nlm.nih.gov/pubmed/25916896)

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy. [ 2015, Montero, et al, 2015, Cell ](http://www-ncbi-nlm-nih-gov/pubmed/25723171) (Cichowski and Letai labs)

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. [De Raedt, et al, 2014, Nature](http://www.ncbi.nlm.nih.gov/pubmed/25119042) (Cichowski and Bradner labs)

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. [Elia, et al, 2015, Mol Cell ](http://www.ncbi.nlm.nih.gov/pubmed/26051181)(Elledge lab)

Principles of cancer therapy: oncogene and non-oncogene addiction. [Luo, et al, 2009, Nature](http://www.ncbi.nlm.nih.gov/pubmed/19269363) (Elledge lab)