%0 Journal Article %J Trends Cancer %D 2017 %T Necroptosis and Cancer %A Ayaz Najafov %A Chen, Hongbo %A Yuan, Junying %X Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to various inflammatory disorders. Escape from programmed cell death and inflammation play a significant role in cancer, and therefore, investigating the role of necroptosis in cancer has been of high interest. Necroptosis has been shown to promote cancer metastasis and T cells death. Escape from necroptosis via loss of RIPK3 expression is a feature of some cancers. While necroptosis is a promising novel target for cancer therapies, further investigation into its biological role in carcinogenesis is warranted. In this article, we review the recently-identified interplay points between necroptosis and cancer, and outline major biological questions that require further inquiry on the road to targeting this pathway in cancer. %B Trends Cancer %V 3 %P 294-301 %8 2017 Apr %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/28451648?dopt=Abstract %R 10.1016/j.trecan.2017.03.002