@article {924486,
	title = {An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.},
	journal = {Nat Genet},
	volume = {48},
	number = {3},
	year = {2016},
	month = {2016 Mar},
	pages = {265-72},
	abstract = {Translocation events are frequent in cancer and may create chimeric fusions or {\textquoteright}regulatory rearrangements{\textquoteright} that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole-genome sequencing data and chromatin maps highlight distinct chromosomal rearrangements that juxtapose super-enhancers to the MYB locus. Chromosome conformation capture confirms that the translocated enhancers interact with the MYB promoter. Remarkably, MYB protein binds to the translocated enhancers, creating a positive feedback loop that sustains its expression. MYB also binds enhancers that drive different regulatory programs in alternate cell lineages in ACC, cooperating with TP63 in myoepithelial cells and a Notch program in luminal epithelial cells. Bromodomain inhibitors slow tumor growth in ACC primagraft models in vivo. Thus, our study identifies super-enhancer translocations that drive MYB expression and provides insight into downstream MYB functions in alternate ACC lineages.},
	keywords = {Carcinoma, Adenoid Cystic, Cell Line, Tumor, Cell Lineage, Chromatin, Enhancer Elements, Genetic, Gene Expression Regulation, Neoplastic, Humans, Oncogene Proteins v-myb, Oncogene Proteins, Fusion, Transcription Factors, Translocation, Genetic, Tumor Suppressor Proteins},
	issn = {1546-1718},
	doi = {10.1038/ng.3502},
	author = {Drier, Yotam and Cotton, Matthew J and Williamson, Kaylyn E and Gillespie, Shawn M and Ryan, Russell J H and Kluk, Michael J and Carey, Christopher D and Rodig, Scott J and Sholl, Lynette M and Afrogheh, Amir H and Faquin, William C and Queimado, Lurdes and Qi, Jun and Wick, Michael J and El-Naggar, Adel K and Bradner, James E and Moskaluk, Christopher A and Aster, Jon C and Knoechel, Birgit and Bernstein, Bradley E}
}
