@article {1656929, title = {Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer}, journal = {Commun Biol}, volume = {5}, number = {1}, year = {2022}, month = {2022 05 02}, pages = {403}, abstract = {Estrogen receptor (ER) positive breast cancer represents 75\% of all breast cancers in women. Although patients with ER+ cancers receive endocrine therapies, more than 30\% develop resistance and succumb to the disease, highlighting the need to understand endocrine resistance. Here we show an unexpected role for the cell polarity protein SCRIB as a tumor-promoter and a regulator of endocrine resistance in ER-positive breast cancer cells. SCRIB expression is induced by estrogen signaling in a MYC-dependent manner. SCRIB interacts with SLC3A2, a heteromeric component of leucine amino acid transporter SLC7A5. SLC3A2 binds to the N-terminus of SCRIB to facilitate the formation of SCRIB/SLC3A2/LLGL2/SLC7A5 quaternary complex required for membrane localization of the amino acid transporter complex. Both SCRIB and SLC3A2 are required for cell proliferation and tamoxifen resistance in ER+ cells identifying a new role for the SCRIB/SLC3A2 complex in ER+ breast cancer.}, keywords = {Breast Neoplasms, Cell Proliferation, Cytoskeletal Proteins, Drug Resistance, Neoplasm, Estrogens, Female, Fusion Regulatory Protein 1, Heavy Chain, Humans, Large Neutral Amino Acid-Transporter 1, Membrane Proteins, Receptors, Estrogen, Tamoxifen, Tumor Suppressor Proteins}, issn = {2399-3642}, doi = {10.1038/s42003-022-03363-3}, author = {Saito, Yasuhiro and Matsuda, Shiori and Ohnishi, Naomi and Endo, Keiko and Ashitani, Sanae and Ohishi, Maki and Ueno, Ayano and Tomita, Masaru and Ueda, Koji and Soga, Tomoyoshi and Muthuswamy, Senthil K} }