@article {1656922,
	title = {STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer},
	journal = {NPJ Breast Cancer},
	volume = {8},
	number = {1},
	year = {2022},
	month = {2022 Sep 06},
	pages = {102},
	abstract = {Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy via synthetic lethal effects and by inducing cGAS/STING-mediated immune responses. We demonstrate that compared to monotherapies, combined PARP inhibition and STING agonism results in increased STING pathway activation, greater cytotoxic T-cell recruitment and enhanced dendritic cell activation in BRCA1-deficient breast cancer models. The combination markedly improved anti-tumor efficacy in vivo, with evidence of complete tumor clearance, prolongation of survival and induction of immunologic memory.},
	issn = {2374-4677},
	doi = {10.1038/s41523-022-00471-5},
	author = {Pantelidou, Constantia and Jadhav, Heta and Kothari, Aditi and Liu, Renyan and Wulf, Gerburg M and Guerriero, Jennifer L and Shapiro, Geoffrey I}
}
