@article {1172376,
	title = {Necroptosis and Cancer},
	journal = {Trends Cancer},
	volume = {3},
	number = {4},
	year = {2017},
	month = {2017 Apr},
	pages = {294-301},
	abstract = {Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to various inflammatory disorders. Escape from programmed cell death and inflammation play a significant role in cancer, and therefore, investigating the role of necroptosis in cancer has been of high interest. Necroptosis has been shown to promote cancer metastasis and T cells death. Escape from necroptosis via loss of RIPK3 expression is a feature of some cancers. While necroptosis is a promising novel target for cancer therapies, further investigation into its biological role in carcinogenesis is warranted. In this article, we review the recently-identified interplay points between necroptosis and cancer, and outline major biological questions that require further inquiry on the road to targeting this pathway in cancer.},
	issn = {2405-8033},
	doi = {10.1016/j.trecan.2017.03.002},
	author = {Ayaz Najafov and Chen, Hongbo and Yuan, Junying}
}
